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Selection and Characterization of Human Serum Albumin-specific Porcine scFv Antibodies Using a Phage Display Library

1 Feb 2014

Abstract excerpt

A new single-chain variable fragment (scFv) antibody library was generated and human serum albumin (HSA)-specific clones were characterized to investigate the usefulness of porcine antibodies. Phage libraries were developed from pigs immunized with the model antigen HSA. The library size was 1.5 × 10(7) for kappa (VL) and 1.4 × 10(7) for lambda fragments. Eight HSA-specific clones from the kappa library and one...

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PMID: 24555936
DOI: 10.1089/mab.2013.0068

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