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A method for the generation of combinatorial antibody libraries using pIX phage display

18 Sept 2002

Abstract excerpt

For more than a decade, phage displayed combinatorial antibody libraries have been used to generate and select a wide variety of antibodies. We previously reported that the phage coat proteins pVII and pIX could be used to display the heterodimeric structure of the antibody Fv region. Herein, aspects of this technology were invoked and extended to construct a large, human single-chain Fv (scFv) library of 4.5 x...

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PMID: 12239343
DOI: 10.1073/pnas.192467999

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