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Article

Convergent evolution in European and Rroma populations reveals pressure exerted by plague on Toll-like receptors.

Proceedings of the National Academy of Sciences of the United States of America - 18 Feb 2014

Laayouni Hafid, Oosting Marije, Luisi Pierre, Ioana Mihai, Alonso Santos, Ricaño-Ponce Isis, Trynka Gosia, Zhernakova Alexandra, Plantinga Theo S, Cheng Shih-Chin, van der Meer Jos W M, Popp Radu, Sood Ajit, Thelma B K, Wijmenga Cisca, Joosten Leo A B, Bertranpetit Jaume, Netea Mihai G

Abstract excerpt

Recent historical periods in Europe have been characterized by severe epidemic events such as plague, smallpox, or influenza that shaped the immune system of modern populations. This study aims to identify signals of convergent evolution of the immune system, based on the peculiar demographic history in which two populations with different genetic ancestry, Europeans and Rroma (Gypsies), have lived in the same...

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Source

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Identifiers

PMID: 24550294
DOI: 10.1073/pnas.1317723111
PMCID: PMC3932890

Genes

TLR1
TLR10
TLR6
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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