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Article

The evolutionary landscape of cytosolic microbial sensors in humans.

American journal of human genetics - 13 Jul 2012

Vasseur Estelle, Boniotto Michele, Patin Etienne, Laval Guillaume, Quach Hélène, Manry Jeremy, Crouau-Roy Brigitte, Quintana-Murci Lluis

Abstract excerpt

Host-pathogen interactions are generally initiated by host recognition of microbial components or danger signals triggered by microbial invasion. This recognition involves germline-encoded microbial sensors or pattern-recognition receptors (PRRs). By studying the way in which natural selection has driven the evolution of these microbial sensors in humans, we can identify genes playing an essential role and...

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Source

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Identifiers

PMID: 22748209
DOI: 10.1016/j.ajhg.2012.05.008
PMCID: PMC3397270

Genes

CIITA
NLRP1
NLRP14

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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