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Functional screening reveals Toxoplasma prenylated proteins required for endocytic trafficking and rhoptry protein sorting

7 Aug 2023

Abstract excerpt

ABSTRACT In the apicomplexans, endocytosed cargos (e.g., hemoglobin) are trafficked to a specialized organelle for digestion. This follows a unique endocytotic process at the micropore/cytostome in these parasites. However, the mechanism underlying endocytic trafficking remains elusive, due to the repurposing of classical endocytic proteins for the biogenesis of apical organelles. To resolve this issue, we have...

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PMID: 37548452
DOI: 10.1128/mbio.01309-23

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