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Article

Structure-Function Dissection of Pseudorabies Virus Glycoprotein B Fusion Loops.

Journal of virology - 1 Jan 2018

Vallbracht Melina, Brun Delphine, Tassinari Matteo, Vaney Marie-Christine, Pehau-Arnaudet Gérard, Guardado-Calvo Pablo, Haouz Ahmed, Klupp Barbara G, Mettenleiter Thomas C, Rey Felix A, Backovic Marija

Abstract excerpt

Conserved across the family Herpesviridae, glycoprotein B (gB) is responsible for driving fusion of the viral envelope with the host cell membrane for entry upon receptor binding and activation by the viral gH/gL complex. Although crystal structures of the gB ectodomains of several herpesviruses have been reported, the membrane fusion mechanism has remained elusive. Here, we report the X-ray structure of the...

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Identifiers

PMID: 29046441
DOI: 10.1128/JVI.01203-17
PMCID: PMC5730762

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Source receipt: pubmed, retrieved 7 Sept 2026.

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