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Dry eye disease in mice activates adaptive corneal epithelial regeneration distinct from constitutive renewal in homeostasis

3 Jan 2023

Abstract excerpt

Many epithelial compartments undergo constitutive renewal in homeostasis but activate unique regenerative responses following injury. The clear corneal epithelium is crucial for vision and is renewed from limbal stem cells (LSCs). Using single-cell RNA sequencing, we profiled the mouse corneal epithelium in homeostasis, aging, diabetes, and dry eye disease (DED), where tear deficiency predisposes the cornea to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 36595669
DOI: 10.1073/pnas.2204134120

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