Leptin Rs7799039 polymorphism is associated with type 2 diabetes mellitus Egyptian patients.

doi:10.1080/13813455.2023.2265078

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Leptin Rs7799039 polymorphism is associated with type 2 diabetes mellitus Egyptian patients.

Archives of physiology and biochemistry - 1 Dec 2024

Mohamed Amal Ahmed, Abo-Elmatty Dina M, Wahba Alaa S, Esmail Omnia Ezzat, Salim Hadeer Saied Mahmoud, Hegab Wafaa Salah Mohammed, Ghanem Mona Mostafa Farid, Riad Nadia Youssef, Ghaith Doaa, Daker Lamiaa I, Issa Shorouk, Radwan Noha Hassan, Sultan Eman, Azzam Omar Mohamoud, El-Shoura Ehab A M

Abstract excerpt

BACKGROUND: Leptin (LEP) is an anti-obesity hormone that regulates food intake, energy expenditure, and glucose metabolism. The genetic variants in LEP and the LEP receptor (LEPR) gene may play an important role in the pathogenesis of type 2 diabetes mellitus (T2DM) and obesity. The current study aimed to investigate the association of serum LEP levels, and LEP polymorphisms in LEP (rs7799039, 2548 G/A) with T2DM...

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PMID: 37840222
DOI: 10.1080/13813455.2023.2265078

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