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Article

Genetic variants in fas signaling pathway genes and risk of gastric cancer.

International journal of cancer - 15 Feb 2014

Hyland Paula L, Lin Shih-Wen, Hu Nan, Zhang Han, Wang Lemin, Su Hua, Wang Chaoyu, Ding Ti, Tang Ze-Zhong, Fan Jin-Hu, Qiao You-Lin, Xiong Xiaoqin, Wheeler William, Giffen Carol, Yu Kai, Yuenger Jeff, Burdett Laurie, Wang Zhaoming, Chanock Stephen J, Tucker Margaret A, Dawsey Sanford M, Freedman Neal D, Goldstein Alisa M, Abnet Christian C, Taylor Philip R

Abstract excerpt

Populations in north central China are at high risk for gastric cancers (GC), and altered FAS-mediated cell signaling and/or apoptosis may contribute to this risk. We examined the association of 554 single nucleotide polymorphisms (SNPs) in 53 Fas signaling-related genes using a pathway-based approach in 1758 GC cases (1126 gastric cardia adenocarcinomas (GCA) and 632 gastric noncardia adenocarcinomas (GNCA)),...

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Source

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Identifiers

PMID: 23921907
DOI: 10.1002/ijc.28415
PMCID: PMC3858487

Genes

GCA
FAF1
MAPK8
CASP10
CASP8
CFLAR
FAS
IKBKB
PAK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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