Article
Higher polygenic risk for melanoma is associated with improved survival in a high ultraviolet radiation setting.
Journal of translational medicine - 5 Sept 2022
Seviiri Mathias, Scolyer Richard A, Bishop D Timothy, Newton-Bishop Julia A, Iles Mark M, Lo Serigne N, Stretch Johnathan R, Saw Robyn P M, Nieweg Omgo E, Shannon Kerwin F, Spillane Andrew J, Gordon Scott D, Olsen Catherine M, Whiteman David C, Landi Maria Teresa, Thompson John F, Long Georgina V, MacGregor Stuart, Law Matthew H
Abstract excerpt
BACKGROUND: The role of germline genetic factors in determining survival from cutaneous melanoma (CM) is not well understood. OBJECTIVE: To perform a genome-wide association study (GWAS) meta-analysis of melanoma-specific survival (MSS), and test whether a CM-susceptibility polygenic risk score (PRS) is associated with MSS. METHODS: We conducted two Cox proportional-hazard GWAS of MSS using data from the Melanoma...
Topics
- Genetic Predisposition to Disease
- Genome-Wide Association Study
- Humans
- Melanoma
- Polymorphism, Single Nucleotide
- Skin Neoplasms
- Ultraviolet Rays
- Melanoma, Cutaneous Malignant