Article
Influence of CYP2C19 loss-of-function variants on the antiplatelet effects and cardiovascular events in clopidogrel-treated Chinese patients undergoing percutaneous coronary intervention.
European journal of clinical pharmacology - 1 Apr 2013
Zou Jian-Jun, Xie Hong-Guang, Chen Shao-Liang, Tan Jie, Lin Ling, Zhao Ying-Ying, Xu Hai-Mei, Lin Song, Zhang Juan, Wang Guang-Ji
Abstract excerpt
BACKGROUND AND OBJECTIVES: A large number of clinical studies have well demonstrated that the loss-of-function variant allele CYP2C19 2 is associated with attenuated response to clopidogrel and increased risk of developing stent thrombosis (ST) in white or black patients with stenting. However, similar association studies on the effect of the CYP2C19 2 and 3 variants on maximum platelet aggregation (MPA) and the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.