Article
Effects of CYP2C19 variant alleles on postclopidogrel platelet reactivity and clinical outcomes in an actual clinical setting in China.
Pharmacogenetics and genomics - 1 Dec 2012
Wu Hongyi, Qian Juying, Xu Jianfeng, Sun Aijun, Sun Wenzhu, Wang Qibing, Ge Junbo
Abstract excerpt
Whether the current pharmacogenetic knowledge of clopidogrel could be translated into Chinese clinical practice is yet to be defined. To address this issue, we assessed the relation of single nucleotide polymorphisms within genes modulating clopidogrel absorption (ABCB1), metabolic activation (CYP2B6, CYP2D6, CYP3A4, CYP2C9, and CYP2C19), and biologic activity (P2RY12) to the response of clopidogrel as measured...
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