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Article

Investigating the role of eight SNPs in CHRNA3 for COPD susceptibility in the Chinese elderly population.

Annals of medicine - 1 Dec 2025

Zheng Yamei, Zhao Jie, Liu Meihua, Liu Yunchan, Ding Yipeng, Xie Tian

Abstract excerpt

BACKGROUND: Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality among the elderly in China. Genetic predisposition is a recognized risk factor for COPD, with CHRNA3 emerging as a promising candidate gene due to its involvement in smoking behavior and lung function. This study aimed to investigate the association between eight CHRNA3 SNPs and COPD susceptibility in the...

Read the complete abstract on PubMed

Topics

Aged
Female
Humans
Male
Middle Aged
Case-Control Studies
China

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Genetic Predisposition to Disease

Genotype

Haplotypes

Linkage Disequilibrium

Polymorphism, Single Nucleotide

Pulmonary Disease, Chronic Obstructive

Receptors, Nicotinic

Risk Factors

East Asian People

Source

Open in PubMed Open full text

Identifiers

PMID: 40072291
DOI: 10.1080/07853890.2025.2474726
PMCID: PMC11905312

Genes

CHRNA3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 21 Oct 2026.

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