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Article

IDH1 p.R132 mutations may not be actively involved in the carcinogenesis of hepatocellular carcinoma.

Medical science monitor : international medical journal of experimental and clinical research - 14 Feb 2014

Lu Jun, Xu Ling, Zou Yang, Yang Run-Xiang, Fan Yu, Zhang Wen, Yu Dandan, Yao Yong-Gang

Abstract excerpt

BACKGROUND: Recent studies have identified prevalent isocitrate dehydrogenase 1 (IDH1) codon 132 mutations (p.R132) in gliomas and acute myeloid leukemia (AML). The IDH1 mutations lead to a loss of its normal enzymatic activity and acquisition of neomorphic activity in production of alpha-ketoglutarate (alpha-KG) and 2-hydroxyglutarate (2-HG), which finally cause alterations of multiple gene expression of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24531386
DOI: 10.12659/MSM.889891
PMCID: PMC3930585

Genes

IDH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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IDH1 p.R132 mutations may not be actively involved in the carcinogenesis of hepatocellular carcinoma.PMID 24531386Read ↗

IDH1 mutations at residue p.R132 (IDH1(R132)) occur frequently in high-grade gliomas but not in other solid tumors.Semantic proximity Read ↗

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D-2-Hydroxyglutarate producing neo-enzymatic activity inversely correlates with frequency of the type of isocitrate dehydrogenase 1 mutations found in glioma.Semantic proximity Read ↗

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