Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Low expression of isocitrate dehydrogenase 1 (IDH1) R132H is associated with advanced pathological features in laryngeal squamous cell carcinoma.

Journal of cancer research and clinical oncology - 1 Jul 2023

Shayanfar Nasrin, Zare-Mirzaie Ali, Mohammadpour Mahsa, Jafari Ensieh, Mehrtash Amirhosein, Emtiazi Nikoo, Tajik Fatemeh

Abstract excerpt

INTRODUCTION: Recent developments in genomic sequencing have led to the identification of somatic mutations in isocitrate dehydrogenase 1 (IDH1) in various malignancies. IDH1 R132H is the most common mutation of IDH1, which affects codon 132 and results in the conversion of amino acid residue arginine (R) to histidine (H). This study is designed to evaluate the association between the expression of IDH1 R132H and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Brain Neoplasms
Share to Glioma

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Head and Neck Neoplasms

Share to Isocitrate Dehydrogenase

Share to Mutation

Share to Squamous Cell Carcinoma of Head and Neck

Source

Identifiers

PMID: 36063222
DOI: 10.1007/s00432-022-04336-z

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Low expression of isocitrate dehydrogenase 1 (IDH1) R132H is associated with advanced pathological features in laryngeal squamous cell carcinoma.PMID 36063222Read ↗

Low expression of Isocitrate Dehydrogenase 1 (IDH1) R132H is associated with advanced pathological features in laryngeal squamous cell carcinomaSemantic proximity Read ↗

Determination of Isocitrate Dehydrogenase (IDH1) mutation in laryngeal squamous cell carcinoma specimensSemantic proximity Read ↗

Decreased expression of IDH1-R132H correlates with poor survival in gastrointestinal cancer.Semantic proximity Read ↗

IDH1 mutations at residue p.R132 (IDH1(R132)) occur frequently in high-grade gliomas but not in other solid tumors.Semantic proximity Read ↗

Immunohistochemical analysis of 1844 human epithelial and haematopoietic tumours and sarcomas for IDH1R132H mutation.Semantic proximity Read ↗

Identification of several novel non-p.R132 IDH1 variants in thyroid carcinomas.Semantic proximity Read ↗

R132 mutations in canine isocitrate dehydrogenase 1 (IDH1) lead to functional changes.Semantic proximity Read ↗

IDH1 p.R132 mutations may not be actively involved in the carcinogenesis of hepatocellular carcinoma.Semantic proximity Read ↗

Association of IDH1 mutations with survival and recurrence in resected intrahepatic cholangiocarcinoma received or not received adjuvant chemotherapy.Semantic proximity Read ↗

IDH1R132H Promotes Malignant Transformation of Benign Prostatic Epithelium by Dysregulating MicroRNAs: Involvement of IGF1R-AKT/STAT3 Signaling Pathway.Semantic proximity Read ↗

R132H mutation in IDH1 gene reduces proliferation, cell survival and invasion of human glioma by downregulating Wnt/β-catenin signaling.Semantic proximity Read ↗

[Expression of isocitrate dehydrogenase 1 gene R132H and its diagnostic application in glioma].Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.