Article
D-2-Hydroxyglutarate producing neo-enzymatic activity inversely correlates with frequency of the type of isocitrate dehydrogenase 1 mutations found in glioma.
Acta neuropathologica communications - 14 Feb 2014
Pusch Stefan, Schweizer Leonille, Beck Ann-Christin, Lehmler Johanna-Marie, Weissert Susanne, Balss Jörg, Miller Aubry K, von Deimling Andreas
Abstract excerpt
BACKGROUND: IDH mutations frequently occur in diffuse gliomas and result in a neo-enzymatic activity that results in reduction of α-ketoglutarate to D-2-hydroxyglutarate. In gliomas, the frequency of IDH1 mutations in codon 132 increases in the order R132L-R132S-R132G-R132C-R132H with R132H constituting more than 90% of all IDH1 mutations. RESULTS: We determined the levels of D-2-hydroxyglutarate in glioma...
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