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Article

825T allele of the G-protein beta3 subunit gene (GNB3) is associated with impaired left ventricular diastolic filling in essential hypertension.

Journal of hypertension - 1 Oct 1999

Jacobi J, Hilgers K F, Schlaich M P, Siffert W, Schmieder R E

Abstract excerpt

OBJECTIVE: Recently, a novel C825T polymorphism in the gene (GNB3) encoding for the G-protein beta3 subunit was identified. The 825T allele is associated with the generation of a novel splice variant, enhanced intracellular signal transduction, and arterial hypertension. In this study, we investigated the impact of the 825T allele on left ventricular structure and function in mild to moderate essential...

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Source

Identifiers

PMID: 10526907
DOI: 10.1097/00004872-199917100-00014

Genes

GNB3
ACE

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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825T allele of the G-protein beta3 subunit gene (GNB3) is associated with impaired left ventricular diastolic filling in essential hypertension.PMID 10526907Read ↗

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G-Protein beta3 subunit C825T variant and ambulatory blood pressure in essential hypertension.Semantic proximity Read ↗

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