Article
G-Protein beta(3) subunit gene variant and left ventricular hypertrophy in essential hypertension.
Hypertension (Dallas, Tex. : 1979) - 1 Jan 2000
Poch E, González D, Gómez-Angelats E, Enjuto M, Paré J C, Rivera F, de La Sierra A
Abstract excerpt
A functional genetic variant consisting of a C825T substitution in the GNB3 gene, encoding for the G-protein beta(3) subunit, has been associated with enhanced G-protein activation and cell growth. The aim of the study was to investigate the association of this polymorphism with left ventricular hypertrophy (LVH) in a sample of patients with essential hypertension. Left ventricular mass was assessed by 2-mode...
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