Article
Leukotriene haplotype × diet interaction on carotid artery hypertrophy and atherosclerosis in American Indians: the Strong Heart Family Study.
Atherosclerosis - 1 Mar 2014
Zhao Jinying, Roman Mary J, Devereux Richard B, Yeh Fawn, Zhang Ying, Haack Karin, Best Lyle G, Cole Shelley A, Lee Elisa T, Howard Barbara V
Abstract excerpt
OBJECTIVE: Gene × diet interaction plays an important role in atherosclerosis, an inflammatory disorder. Leukotrienes are the most potent inflammatory mediators, and genetic variants encoding leukotriene genes have been implicated in atherosclerosis. This study tests nutrigenetic interaction of a previously defined leukotriene haplotype on carotid artery hypertrophy and atherosclerosis in American Indians....
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