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Article

Genetic analyses of circulating PUFA-derived mediators identifies heritable dihydroxyeicosatrienoic acid species.

Prostaglandins & other lipid mediators - 1 Jun 2022

McGurk Kathryn A, Farrell Laura, Kendall Alexandra C, Keavney Bernard D, Nicolaou Anna

Abstract excerpt

Estimates of heritability are the first step in identifying a trait with substantial variation due to genetic factors. Large-scale genetic analyses can identify the DNA variants that influence the levels of circulating lipid species and the statistical technique Mendelian randomisation can use these DNA variants to address potential causality of these lipids in disease. We estimated the heritability of plasma...

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PMID: 35472599
DOI: 10.1016/j.prostaglandins.2022.106638

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