Article
The ABCG8 G574R variant, serum plant sterol levels, and cardiovascular disease risk in the Old Order Amish.
Arteriosclerosis, thrombosis, and vascular biology - 1 Feb 2013
Horenstein Richard B, Mitchell Braxton D, Post Wendy S, Lütjohann Dieter, von Bergmann Klaus, Ryan Kathleen A, Terrin Michael, Shuldiner Alan R, Steinle Nanette I
Abstract excerpt
OBJECTIVE: To determine whether long-term exposure to moderate elevations in plasma plant sterol levels increases risk for atherosclerosis. METHODS AND RESULTS: In Old Order Amish participants aged 18 to 85 years, with (n=110) and without (n=181) 1 copy of the ABCG8 G574R variant, we compared mean plasma levels of plant sterols and cholesterol precursors and carotid intima-media wall thickness. Carriers of a...
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