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Functional analysis of single cells identifies a rare subset of circulating tumor cells with malignant traits

5 Feb 2014

Abstract excerpt

Ample evidence supports genetic and functional heterogeneity in primary tumors, but it remains unclear whether circulating tumor cells (CTCs) also exhibit the same hierarchical organization. We examined the functional diversity of viable, single CTCs using an array of subnanoliter wells (nanowells). The compartmentalization of single cells by nanowells allowed clonal comparison and mapping of heterogeneity of...

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PMID: 24522233
DOI: 10.1039/c3ib40264a

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