Article
Characterization of HelD, an interacting partner of RNA polymerase from Bacillus subtilis.
Nucleic acids research - 1 Apr 2014
Wiedermannová Jana, Sudzinová Petra, Kovaľ Tomaš, Rabatinová Alžbeta, Šanderova Hana, Ramaniuk Olga, Rittich Šimon, Dohnálek Jan, Fu Zhihui, Halada Petr, Lewis Peter, Krásny Libor
Abstract excerpt
Bacterial RNA polymerase (RNAP) is an essential multisubunit protein complex required for gene expression. Here, we characterize YvgS (HelD) from Bacillus subtilis, a novel binding partner of RNAP. We show that HelD interacts with RNAP-core between the secondary channel of RNAP and the alpha subunits. Importantly, we demonstrate that HelD stimulates transcription in an ATP-dependent manner by enhancing...
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