Article
Structural and functional characterization of partner switching regulating the environmental stress response in Bacillus subtilis.
The Journal of biological chemistry - 13 Apr 2007
Hardwick Steven W, Pané-Farré Jan, Delumeau Olivier, Marles-Wright Jon, Murray James W, Hecker Michael, Lewis Richard J
Abstract excerpt
The general stress response of Bacillus subtilis and close relatives provides the cell with protection from a variety of stresses. The upstream component of the environmental stress signal transduction cascade is activated by the RsbT kinase that switches binding partners from a 25 S macromolecular complex, the stressosome, to the RsbU phosphatase. Once the RsbU phosphatase is activated by interacting with RsbT,...
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