Article
Human longevity and variation in DNA damage response and repair: study of the contribution of sub-processes using competitive gene-set analysis.
European journal of human genetics : EJHG - 1 Sept 2014
Debrabant Birgit, Soerensen Mette, Flachsbart Friederike, Dato Serena, Mengel-From Jonas, Stevnsner Tinna, Bohr Vilhelm A, Kruse Torben A, Schreiber Stefan, Nebel Almut, Christensen Kaare, Tan Qihua, Christiansen Lene
Abstract excerpt
DNA-damage response and repair are crucial to maintain genetic stability, and are consequently considered central to aging and longevity. Here, we investigate whether this pathway overall associates to longevity, and whether specific sub-processes are more strongly associated with longevity than others. Data were applied on 592 SNPs from 77 genes involved in nine sub-processes: DNA-damage response, base excision...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.