Article
Increased age-adjusted hazard of death associated with a common single nucleotide polymorphism of the human RAD52 gene in a cardiovascular cohort.
Mechanisms of ageing and development - 1 Oct 2017
Lenart Peter, Zlámal Filip, Machal Jan, Hlinomaz Ota, Groch Ladislav, Bienertová-Vašků Julie
Abstract excerpt
Aging may be characterized as the progressive increase of the risk of death caused by a decrease of almost all bodily functions. While a great number of model organism studies have established the role of DNA double strand breaks (DSBs) as one of the main causes of aging, few studies have examined whether common polymorphisms in human DSB repair genes influence aging and mortality. More importantly, to the best...
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