Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Contribution of genetic polymorphisms on functional status at very old age: a gene-based analysis of 38 genes (311 SNPs) in the oxidative stress pathway.

Experimental gerontology - 1 Apr 2014

Dato S, Soerensen M, Lagani V, Montesanto A, Passarino G, Christensen K, Tan Q, Christiansen L

Abstract excerpt

Preservation of functional ability is a well-recognized marker of longevity. At a molecular level, a major determinant of the physiological decline occurring with aging is the imbalance between production and accumulation of oxidative damage to macromolecules, together with a decreased efficiency of stress response to avoid or repair such damage. In this paper we investigated the association of 38 genes (311...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Activities of Daily Living
Share to Aged

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Aged, 80 and over

Share to Cognition

Share to CCS gene

Share to UCP3 gene

Share to Oxidative Stress

Share to Polymorphism, Single Nucleotide

Source

Open in PubMed Open full text

Identifiers

PMID: 24462499
DOI: 10.1016/j.exger.2014.01.014
PMCID: PMC4050201

Genes

TXNRD1
UCP3
NDUFS1
CCS
GCLC
GLRX
GSTP1
NDUFV1
SOD2
UCP2
UQCRFS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Contribution of genetic polymorphisms on functional status at very old age: a gene-based analysis of 38 genes (311 SNPs) in the oxidative stress pathway.PMID 24462499Read ↗

Antioxidants and Quality of Aging: Further Evidences for a Major Role of TXNRD1 Gene Variability on Physical Performance at Old Age.Semantic proximity Read ↗

Genetic variation and human longevity.Semantic proximity Read ↗

No Association between Variation in Longevity Candidate Genes and Aging-related Phenotypes in Oldest-old Danes.Semantic proximity Read ↗

Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study.Semantic proximity Read ↗

Polygenic markers of survival and longevity in the antioxidant genes PON1, PON2, MTHFR, MSRA, SOD1, NQO1, and CAT in a 20-year follow-up study in the population from the Volga-Ural region.Semantic proximity Read ↗

UCP3 polymorphisms, hand grip performance and survival at old age: association analysis in two Danish middle aged and elderly cohorts.Semantic proximity Read ↗

Oxidative stress, human genetic variation, and disease.Semantic proximity Read ↗

The Mn-superoxide dismutase single nucleotide polymorphism rs4880 and the glutathione peroxidase 1 single nucleotide polymorphism rs1050450 are associated with aging and longevity in the oldest old.Semantic proximity Read ↗

Nutrigenomics: SNPs correlated to detoxification, antioxidant capacity and longevity.Semantic proximity Read ↗

Oxidative stress, telomere length and biomarkers of physical aging in a cohort aged 79 years from the 1932 Scottish Mental Survey.Semantic proximity Read ↗

rs2070424 of the SOD1 gene is associated with risk of Alzheimer's disease.Semantic proximity Read ↗

Genes Involved in DNA Damage Cell Pathways and Health of the Oldest-Old (85+).Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.