An allele of HRAS1 3'variable number of tandem repeats is a frailty allele: implication for an evolutionarily-conserved pathway involved in longevity.

doi:10.1016/s0378-1119(01)00812-5

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An allele of HRAS1 3'variable number of tandem repeats is a frailty allele: implication for an evolutionarily-conserved pathway involved in longevity.

Gene - 6 Mar 2002

Bonafè Massimiliano, Barbi Cristiana, Olivieri Fabiola, Yashin Anatoli, Andreev Kirill F, Vaupel James W, De Benedictis Giovanna, Rose Giuseppina, Carrieri Giuseppina, Jazwinski S Michal, Franceschi Claudio

Abstract excerpt

The human HRAS1 belongs to an evolutionarily-conserved family of genes which enrolls among its members the yeast RAS2, a gene which regulates stress response and longevity in the Saccharomyces cerevisiae. In this paper we report that the frequency of the a3 allele of HRAS1 3'variable number tandem repeat (HRAS1 3'VNTR) decreases in centenarians in respect to young people, and we estimate that during aging a3...

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An allele of HRAS1 3'variable number of tandem repeats is a frailty allele: implication for an evolutionarily-conserved pathway involved in longevity.

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