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Article

Oxidative stress is not a major contributor to somatic mitochondrial DNA mutations.

PLoS genetics - 1 Feb 2014

Itsara Leslie S, Kennedy Scott R, Fox Edward J, Yu Selina, Hewitt Joshua J, Sanchez-Contreras Monica, Cardozo-Pelaez Fernando, Pallanck Leo J

Abstract excerpt

The accumulation of somatic mitochondrial DNA (mtDNA) mutations is implicated in aging and common diseases of the elderly, including cancer and neurodegenerative disease. However, the mechanisms that influence the frequency of somatic mtDNA mutations are poorly understood. To develop a simple invertebrate model system to address this matter, we used the Random Mutation Capture (RMC) assay to characterize the...

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Identifiers

PMID: 24516391
DOI: 10.1371/journal.pgen.1003974
PMCID: PMC3916223

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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