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Article

Moxifloxacin retains antimycobacterial activity in the presence of gyrA mutations.

Antimicrobial agents and chemotherapy - 1 May 2014

McGrath Marieta, Gey van Pittius Nico C, Sirgel Frederick A, Van Helden Paul D, Warren Robin M

Abstract excerpt

Moxifloxacin-resistant Mycobacterium tuberculosis mutants were selected in vitro using different concentrations of moxifloxacin. gyrA mutations at codons 88 and 94 were associated with resistance (defined as an MIC of ≥2 μg/ml) (P < 0.0001 and P = 0.0053, respectively). Despite the presence of gyrA mutations, moxifloxacin significantly impedes bacterial growth, supporting its use for the treatment of...

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Identifiers

PMID: 24514091
DOI: 10.1128/AAC.02583-13
PMCID: PMC3993264

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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