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Article

Characterizing the gene mutations associated with resistance to gatifloxacin in Mycobacterium tuberculosis through whole-genome sequencing.

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases - 1 Nov 2021

Bi Jing, Guo Qinglong, Fu Xiangdong, Liang Juan, Zeng Lidong, Ou Min, Zhang Juanjuan, Wang Zhaoqin, Sun Yicheng, Liu Lei, Zhang Guoliang

Abstract excerpt

OBJECTIVES: Gatifloxacin (GAT), a fourth-generation fluoroquinolone (FQ), is used to treat drug-resistant tuberculosis. Although DNA gyrase mutations are the leading cause of FQ resistance, mutations conferring resistance to GAT remain inadequately characterized. METHODS: GAT-resistant mutants were selected from 7H10 agar plates containing 0.5 mg/L GAT (critical concentration). Mutations involved in GAT...

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Identifiers

PMID: 34547490
DOI: 10.1016/j.ijid.2021.09.028

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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