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Gemifloxacin resistance in Mycobacterium tuberculosis without QRDR mutations in gyrA or gyrB: evidence for non-canonical resistance mechanisms.

Microbiology spectrum - 7 Jul 2026

Hekmatpour Niloofar, Hajizadeh Mina, Yousefi Shirin, Marjani Majid, Tarashi Samira, Siadat Seyed Davar

Abstract excerpt

Tuberculosis (TB) remains a global health threat, with multidrug-resistant TB (MDR-TB) presenting major therapeutic challenges. Fluoroquinolones (FQs) are key second-line drugs. Resistance is typically linked to mutations within quinolone resistance-determining regions (QRDRs), though non-canonical mechanisms are increasingly recognized. To evaluate phenotypic susceptibility to gemifloxacin in clinical...

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PMID: 42294717
DOI: 10.1128/spectrum.03710-25
PMCID: PMC13339805

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