Article
Functional characterization of variants in MC4R gene promoter region found in obese children.
The Journal of clinical endocrinology and metabolism - 1 May 2014
Tan Karen Mei Ling, Ooi Shu Qin Delicia, Ong Siong Gim, Kwan Charmaine Shuyi, Chan Raymond Ming En, Seng Poh Larry Kok, Mendoza Jedeane, Heng Chew Kiat, Loke Kah Yin, Lee Yung Seng
Abstract excerpt
CONTEXT: Mutations in the MC4R gene are the most common cause of monogenic obesity, and there are few studies on mutations in the promoter region. OBJECTIVE: The objective of the study was to sequence the promoter region of the MC4R gene in a cohort of obese children to identify rare variants. DESIGN, SETTING, AND PATIENTS: A region 1500 bp upstream of the MC4R gene was sequenced in 267 unrelated local children...
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