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Article

Prefoldin prevents aggregation of α-synuclein.

Brain research - 13 Jan 2014

Takano Mariko, Tashiro Erika, Kitamura Akira, Maita Hiroshi, Iguchi-Ariga Sanae M M, Kinjo Masataka, Ariga Hiroyoshi

Abstract excerpt

Protein aggregation is observed in various neurodegeneration diseases, including Parkinson's disease (PD). Alpha-synuclein, a causative gene product of familial PD, is a major component of large aggregates (inclusion bodies) in PD. Prefoldin, a molecular chaperone comprised of six subunits, PFD1~6, prevents misfolding of newly synthesized nascent polypeptides and also prevents aggregation of protein such as a...

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PMID: 24511594

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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