Article
Both familial Parkinson's disease mutations accelerate alpha-synuclein aggregation.
The Journal of biological chemistry - 2 Apr 1999
Narhi L, Wood S J, Steavenson S, Jiang Y, Wu G M, Anafi D, Kaufman S A, Martin F, Sitney K, Denis P, Louis J C, Wypych J, Biere A L, Citron M
Abstract excerpt
Parkinson's disease (PD) is a neurodegenerative disorder that is pathologically characterized by the presence of intracytoplasmic Lewy bodies, the major component of which are filaments consisting of alpha-synuclein. Two recently identified point mutations in alpha-synuclein are the only known genetic causes of PD, but their pathogenic mechanism is not understood. Here we show that both wild type and mutant...
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