Article
Comprehensive data resources and analytical tools for pathological association of aminoacyl tRNA synthetases with cancer.
Database : the journal of biological databases and curation - 1 Jan 2015
Lee Ji-Hyun, You Sungyong, Hyeon Do Young, Kang Byeongsoo, Kim Hyerim, Park Kyoung Mii, Han Byungwoo, Hwang Daehee, Kim Sunghoon
Abstract excerpt
Mammalian cells have cytoplasmic and mitochondrial aminoacyl-tRNA synthetases (ARSs) that catalyze aminoacylation of tRNAs during protein synthesis. Despite their housekeeping functions in protein synthesis, recently, ARSs and ARS-interacting multifunctional proteins (AIMPs) have been shown to play important roles in disease pathogenesis through their interactions with disease-related molecules. However, there...
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