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Article

Copy Number Variation in <i>CCND1</i> Gene Is Implicated in the Pathogenesis of Sporadic Parathyroid Carcinoma

7 Feb 2014

Abstract excerpt

BACKGROUND: The molecular bases for parathyroid carcinomas present in conjunction with sporadic primary hyperparathyroidism are not fully elucidated. Gene copy number variations (CNVs) play an important role in tumorigenesis. The aim of the current study was to explore whether the CNVs of specific tumor-associated genes are involved in parathyroid carcinogenesis. METHODS: A multiplex ligation-dependent probe...

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PMID: 24510244
DOI: 10.1007/s00268-014-2455-9

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