Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Glycosylation at Asn211 regulates the activation state of the discoidin domain receptor 1 (DDR1).

The Journal of biological chemistry - 28 Mar 2014

Fu Hsueh-Liang, Valiathan Rajeshwari R, Payne Leo, Kumarasiri Malika, Mahasenan Kiran V, Mobashery Shahriar, Huang Paul, Fridman Rafael

Abstract excerpt

Discoidin domain receptor 1 (DDR1) belongs to a unique family of receptor tyrosine kinases that signal in response to collagens. DDR1 undergoes autophosphorylation in response to collagen binding with a slow and sustained kinetics that is unique among members of the receptor tyrosine kinase family. DDR1 dimerization precedes receptor activation suggesting a structural inhibitory mechanism to prevent unwarranted...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Motifs
Share to Asparagine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Collagen Type I

Share to Endocytosis

Share to Glycosylation

Share to Protein Multimerization

Share to Protein Structure, Quaternary

Share to Receptor Protein-Tyrosine Kinases

Source

Open in PubMed Open full text

Identifiers

PMID: 24509848
DOI: 10.1074/jbc.M113.541102
PMCID: PMC3979393

Genes

DDR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Glycosylation at Asn211 regulates the activation state of the discoidin domain receptor 1 (DDR1).PMID 24509848Read ↗

Structure of the Discoidin Domain Receptor 1 Extracellular Region Bound to an Inhibitory Fab Fragment Reveals Features Important for SignalingSemantic proximity Read ↗

A network map of discoidin domain receptor 1(DDR1)-mediated signaling in pathological conditionsSemantic proximity Read ↗

A transmembrane leucine zipper is required for activation of the dimeric receptor tyrosine kinase DDR1.Semantic proximity Read ↗

Mechanical signaling through the discoidin domain receptor 1 plays a central role in tissue fibrosisSemantic proximity Read ↗

Discoidin domain receptor tyrosine kinases: new players in cancer progression.Semantic proximity Read ↗

DDR1 and DDR2 physical interaction leads to signaling interconnection but with possible distinct functions.Semantic proximity Read ↗

DDR1 autophosphorylation is a result of aggregation into dense clusters.Semantic proximity Read ↗

Discoidin domain receptor 1 (DDR1): An emerged novel mechanosensorSemantic proximity Read ↗

Identification of the N-linked glycosylation sites of the human relaxin receptor and effect of glycosylation on receptor function.Semantic proximity Read ↗

Mechanism of FGF receptor dimerization and activation.Semantic proximity Read ↗

Notch-Jagged signaling complex defined by an interaction mosaic.Semantic proximity Read ↗

Conformational Freedom of the LRP6 Ectodomain Is Regulated by N-glycosylation and the Binding of the Wnt Antagonist Dkk1.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.