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Article

MGMT promoter hypermethylation is a frequent, early, and consistent event in astrocytoma progression, and not correlated with TP53 mutation.

Journal of neuro-oncology - 1 Feb 2011

Groenendijk Floris H, Taal Walter, Dubbink Hendrikus J, Haarloo Cathleen R, Kouwenhoven Mathilde C, van den Bent Martin J, Kros Johan M, Dinjens Winand N M

Abstract excerpt

Hypermethylation of the MGMT gene promoter and mutation of the TP53 tumor-suppressor gene are frequently present in diffuse astrocytomas. However, there is only anecdotal information about MGMT methylation status and TP53 mutations during progression of low-grade diffuse astrocytoma (AII) to anaplastic astrocytoma (AIII) and secondary glioblastoma (sGB). In this study biopsy specimens from 51 patients with...

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Source

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Identifiers

PMID: 20593220
DOI: 10.1007/s11060-010-0274-x
PMCID: PMC3024495

Genes

MGMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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