Article
A multivariate to multivariate approach for voxel-wise genome-wide association analysis.
Statistics in medicine - 10 Sept 2024
Wu Qiong, Zhang Yuan, Huang Xiaoqi, Ma Tianzhou, Hong L Elliot, Kochunov Peter, Chen Shuo
Abstract excerpt
The joint analysis of imaging-genetics data facilitates the systematic investigation of genetic effects on brain structures and functions with spatial specificity. We focus on voxel-wise genome-wide association analysis, which may involve trillions of single nucleotide polymorphism (SNP)-voxel pairs. We attempt to identify underlying organized association patterns of SNP-voxel pairs and understand the polygenic...
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