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Alternative lengthening of telomeres pathway: Recombination-mediated telomere maintenance mechanism in human cells

11 Oct 2010

Abstract excerpt

Unlimitedly proliferating cells need to acquire the telomere DNA maintenance mechanism, to counteract possible shortening through multiple rounds of replication and segregation of linear chromosomes. Most human cancer cells express telomerase whereas the other cells utilize the alternative lengthening of telomeres (ALT) pathway to elongate telomere DNA. It is suggested that ALT depends on the recombination...

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PMID: 20937668
DOI: 10.1093/jb/mvq119

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