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Cellular stress response, sirtuins and UCP proteins in Alzheimer disease: role of vitagenes

17 Oct 2013

Abstract excerpt

Alzheimer's Disease (AD) is a neurodegenerative disorder affecting up to one third of individuals reaching the age of 80. Different integrated responses exist in the brain to detect oxidative stress which is controlled by several genes termed Vitagenes. Vitagenes encode for cytoprotective heat shock proteins (Hsp), as well as thioredoxin, sirtuins and uncouple proteins (UCPs). In the present study we evaluate...

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PMID: 24498895
DOI: 10.1186/1742-4933-10-41

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