Stress responses, vitagenes and hormesis as critical determinants in aging and longevity: Mitochondria as a “chi”

Abstract excerpt

Understanding mechanisms of aging and determinants of life span will help to reduce age-related morbidity and facilitate healthy aging. Average lifespan has increased over the last centuries, as a consequence of medical and environmental factors, but maximal life span remains unchanged. Extension of maximal life span is currently possible in animal models with measures such as genetic manipulations and caloric...

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