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Article

Loss of WISP2/CCN5 in estrogen-dependent MCF7 human breast cancer cells promotes a stem-like cell phenotype.

PloS one - 1 Jan 2014

Ferrand Nathalie, Gnanapragasam Anne, Dorothee Guillaume, Redeuilh Gérard, Larsen Annette K, Sabbah Michèle

Abstract excerpt

It has been proposed that the epithelial-mesenchymal transition (EMT) in mammary epithelial cells and breast cancer cells generates stem cell features. WISP2 (Wnt-1-induced signaling protein-2) plays an important role in maintenance of the differentiated phenotype of estrogen receptor-positive breast cancer cells and loss of WISP2 is associated with EMT. We now report that loss of WISP2 in MCF7 breast cancer...

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Source

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Identifiers

PMID: 24498388
DOI: 10.1371/journal.pone.0087878
PMCID: PMC3912128

Genes

CCN5
IGFBP7
SMAD3
SOX9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Loss of WISP2/CCN5 in estrogen-dependent MCF7 human breast cancer cells promotes a stem-like cell phenotype.PMID 24498388Read ↗

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