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Article

Gain of oncogenic function of p53 mutants induces invasive phenotypes in human breast cancer cells by silencing CCN5/WISP-2.

Cancer research - 15 Jun 2008

Dhar Gopal, Banerjee Snigdha, Dhar Kakali, Tawfik Ossama, Mayo Matthew S, Vanveldhuizen Peter J, Banerjee Sushanta K

Abstract excerpt

CCN5/WISP-2 is overexpressed in noninvasive breast cancer cells and tissue samples, whereas its expression is minimal or undetected in invasive conditions. CCN5/WISP-2 has been considered as an antiinvasive gene because CCN5/WISP-2 silencing augments the invasive phenotypes in vitro. However, the mechanism of silencing of CCN5 during the progression of the disease has been elusive. Because p53 mutations are...

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Identifiers

PMID: 18559502
DOI: 10.1158/0008-5472.CAN-08-0316

Genes

CCN5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Gain of oncogenic function of p53 mutants induces invasive phenotypes in human breast cancer cells by silencing CCN5/WISP-2.PMID 18559502Read ↗

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