Article
Role of WISP-2/CCN5 in the maintenance of a differentiated and noninvasive phenotype in human breast cancer cells.
Molecular and cellular biology - 1 Feb 2008
Fritah Asmaà, Saucier Cécile, De Wever Olivier, Bracke Marc, Bièche Ivan, Lidereau Rosette, Gespach Christian, Drouot Sylvain, Redeuilh Gérard, Sabbah Michèle
Abstract excerpt
WISP-2/CCN5 is an estrogen-regulated member of the "connective tissue growth factor/cysteine-rich 61/nephroblastoma overexpressed" (CCN) family of the cell growth and differentiation regulators. The WISP-2/CCN5 mRNA transcript is undetectable in normal human mammary cells, as well as in highly aggressive breast cancer cell lines, in contrast with its higher level in the breast cancer cell lines characterized by a...
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