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Article

GNAS mutations identify a set of right-sided, RAS mutant, villous colon cancers.

PloS one - 1 Jan 2014

Fecteau Ryan E, Lutterbaugh James, Markowitz Sanford D, Willis Joseph, Guda Kishore

Abstract excerpt

The purpose of this study is to determine the genetic frequency of GNAS activating mutations in colorectal cancer and the corresponding pathology of GNAS mutant tumors. Oncogenic mutations in GNAS have been described in a number of neoplasms including those of the pituitary, kidney, pancreas, and, more recently, in colon cancer. To ascertain the frequency in colon cancer we employed a sensitive pyrosequencing...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to GTP-Binding Protein alpha Subunits, Gs

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Share to Proto-Oncogene Proteins

Share to Proto-Oncogene Proteins B-raf

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Source

Open in PubMed Open full text

Identifiers

PMID: 24498230
DOI: 10.1371/journal.pone.0087966
PMCID: PMC3907576

Genes

GNAS
BRAF
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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