Article
GNAS mutations are present in colorectal traditional serrated adenomas, serrated tubulovillous adenomas and serrated adenocarcinomas with adverse prognostic features.
Histopathology - 1 Jun 2017
Liu Cheng, McKeone Diane M, Walker Neal I, Bettington Mark L, Leggett Barbara A, Whitehall Vicki L J
Abstract excerpt
AIMS: Activating mutations in GNAS are important in the development of a range of neoplasms, including a small proportion of conventional adenomas and colorectal carcinomas (CRCs). However, their contribution to serrated pathway neoplasia is unclear, as mutations have only been examined in small series of sessile serrated adenomas (SSAs) and traditional serrated adenomas (TSAs), and not in serrated tubulovillous...
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