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Article

Frequent activating GNAS mutations in villous adenoma of the colorectum.

The Journal of pathology - 1 Sept 2012

Yamada Masayoshi, Sekine Shigeki, Ogawa Reiko, Taniguchi Hirokazu, Kushima Ryoji, Tsuda Hitoshi, Kanai Yae

Abstract excerpt

To elucidate the role of GNAS mutations in colorectal tumourigenesis, we performed a mutation analysis in a total of 234 colorectal tumours, including adenomas, serrated lesions and adenocarcinomas. Activating GNAS mutations were found in 20 of the 24 villous adenomas (83%) but were absent in all the other tumours, except for one tubulovillous adenoma (3%) and two adenocarcinomas (3%). KRAS and BRAF mutations...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 22374786
DOI: 10.1002/path.4012

Genes

GNAS
BRAF
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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