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Article

Genetic screening of the genes interacting with Drosophila FIG4 identified a novel link between CMT-causing gene and long noncoding RNAs.

Experimental neurology - 1 Dec 2018

Muraoka Yuuka, Nakamura Aya, Tanaka Ryo, Suda Kojiro, Azuma Yumiko, Kushimura Yukie, Lo Piccolo Luca, Yoshida Hideki, Mizuta Ikuko, Tokuda Takahiko, Mizuno Toshiki, Nakagawa Masanori, Yamaguchi Masamitsu

Abstract excerpt

Neuron-specific knockdown of the dFIG4 gene, a Drosophila homologue of human FIG4 and one of the causative genes for Charcot-Marie-Tooth disease (CMT), reduces the locomotive abilities of adult flies, as well as causing defects at neuromuscular junctions, such as reduced synaptic branch length in presynaptic terminals of the motor neurons in third instar larvae. Eye imaginal disc-specific knockdown of dFIG4...

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Identifiers

PMID: 30165075
DOI: 10.1016/j.expneurol.2018.08.009

Genes

FIG4
FUS

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